July 25, 2025
Bulletin interne de l'Institut Pasteur
Neutralizing human monoclonal antibodies against hepatitis E virus
The Humoral Immunology Unit has identified neutralizing antibodies that are effective against the hepatitis E virus (HEV). They could be used for prevention or treatment against HEV infection, which affects approximately 20 million people worldwide every year. Structural analyses carried out with the NanoImaging Core Facility enabled atomic-scale visualization of the neutralization site recognized by the antibodies. The findings serve as a basis for the rational design of vaccines and immunotherapies against HEV.