CORONAVIRUS

The Institut Pasteur mobilization : new projects

The Institut Pasteur in Paris and its International Network of 32 institutes have been extremely active worldwide in responding with science to the pandemic caused by the SARS-CoV-2 coronavirus. Its response currently involves a lot of people at the Institut Pasteur in Paris and several teams in the network in other countries. A coronavirus task force was set up by the Institut Pasteur in January to coordinate COVID-19 research by its teams. Nearly 60 projects have benefited from the support of the Institut Pasteur. Many projects are also being carried out in partnerships or with the support of other organizations.

Part of these projects is presented on the pasteur.fr website and will be completed very soon. It is currently divided into eight broad research fields:

  • Knowledge of the virus and its pathogenesis

  • Development of research tools

  • Development of diagnostic tests

  • Therapeutic research

  • Vaccine candidates

  • Epidemiological research

  • Modeling

  • Bioinformatics

This week, several new projects led by the IPIN enrich all of the projects carried out to date:

- NicoSars Project: Nicotinic modulation of SARS-CoV-2 infection in the brain

- COVID-Spreads project: Mechanisms of intercellular spreading of SARS-CoV-2: assessing the role of TNTs to escape immune surveillance and expand tropism and pathogenicity

- TROPICORO project (TROPIsm of COROnaviruses): Evaluating the determinants of coronavirus tropism in 3D models of human pulmonary epithelia

- CAPTURE-COV project: Sequence the complete genome of Covid-19 directly and at low cost from prepared RNA samples from patients

- ARISE project: Air monitoring risk area

- CoV2-Anti-protease project: Drug Repurposing & Design to inhibit the SARS-CoV2 proteases

- NeuroCoVidZ project: A zebrafish model to study SARS-CoV-2 neuroinvasion

- Neurological project: Neurological implications of SARS-COV-2 infection – a transversal study

- ROSA project: Restriction of SARS-CoV-2 replication by coding and non-coding genes

- Projet DSAC: Deciphering the virus interactions with the entry receptors in human cells, and their potential inhibition

See the latest news on these research projects as of June 4, 2020

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