Identification of metabolic mechanisms involved in chronic inflammatory bowel disease

A study by scientists from the Institut Pasteur of Shanghai, Chinese Academy of Sciences, published on April 1 in the Journal of Clinical Investigation, revealed that the mTOR metabolic pathway plays a key role in detecting and integrating environmental signals from diet and the microbiota. A high-fat, high-protein diet contributes to gut inflammation and cancer. The study sheds new light on the pathogenesis of chronic inflammatory bowel disease (IBD) and the development of therapeutic approaches for IBD and colorectal cancer.

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