December 20, 2019
Bulletin interne de l'Institut Pasteur
Allogeneic hematopoietic stem cells and human metabolome
A team of hematology marrow transplant department of the Saint-Louis Hospital AP-HP, the Paris University and INSERM (U976 unit) in collaboration with the Pasteur Institute, led the work on graft against host disease (GVHD) using liquid chromatography coupled with mass spectrometry to study the metabolome of allogeneic patients at Saint-Louis hospital AP-HP. The results of these studies highlight major changes in the human metabolome after allograft, associated with the patient's metabolism alterations and its microbiota, and could represent new potential therapeutic targets for the prevention or treatment of GVHD. They were the subject of a publication in December 13, 2019 in the journal Nature Communications.