Regenerative medicine: senescent cells boost cell reprogramming

The major challenge currently faced in the field of regenerative medicine is how to reprogram differentiated adult cells into other cell types for tissue repair. Scientists from the Institut Pasteur and the CNRS have made a surprising discovery that cellular senescence, usually associated with aging, cancer and inflammation, promotes reprogramming, where cells revert back to a more embryonic-like state. Converting cells into this "undifferentiated" state represents an important step in developing cell therapy strategies to replace defective cells in pathological conditions, such as disease and aging.

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