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High-level microscopy unveils bacteria’s adaptation mechanisms

Microorganisms are constantly challenged by a variety of environmental stresses. In many bacteria, the stressosome, a key inducer of the stress response is a very large machine that responds to diverse environmental changes. However, how the stressosome transmits stress signals from the environment has remained elusive. Thanks to high-resolution microscope Titan KriosTM, researchers from the Biology and Genetics of Bacterial Cell Wall and the Bacteria-cell interactions Unit at the Institut Pasteur (Paris) in collaboration with a British group form London UCL took a first step in the roadmap to understanding the structural mechanism underpinning the role of the stressosome in the bacterial stress response.

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