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Understanding how the whooping cough bacterium has evolved in response to vaccination
How do we track the dynamics of a disease, particularly in terms of its response to vaccines? A study published in Science Translational Medicine provides key data on the transmission and dynamics of Bordetella pertussis, the agent that causes whooping cough. It marks the culmination of 5 years' genomic data collection. Besides addressing this specific pathogen, the research has also offered some methodological developments based on mathematical modeling. These tools represent a significant breakthrough in the use of pathogens' genetic data to describe their spatial dynamics...