May 05, 2020
Bulletin interne de l'Institut Pasteur
HIV-1: revealed during the nuclear entry step. Direct visualization in living cells using “HIV-1 ANCHOR” technology
Researchers from Institut Pasteur (Paris), Paris-Descartes University and CNRS, studying HIV-1, have been able to visualize in living cells (direct visualization) the retrotranscribed viral genome, which is capable to integrate into the human genome. They also observed that multiple viral capsid proteins are responsible to lead the retrotranscribed HIV-1 DNA inside the host nucleus. Those direct visualizations are considered a breakthrough in HIV-1 research, and they have been made using the HIV-1 ANCHOR* technology.
*ANCHOR sequences are property of NeoVirTech.