Elucidation of the inhibition mechanism of calmodulin, a protein that is essential for life

Calmodulin is a protein produced naturally by the body whose activity is modulated by the calcium in our cells. Scientists at the Institut Pasteur have elucidated the mechanisms of interaction between calmodulin and calmidazolium. The latter is able to effectively reduce the biological effects of calmodulin, but it is also toxic for cells. This study paves the way for the development of new, more selective calmodulin inhibitors with fewer adverse effects.

Find out more