October 20, 2023
Bulletin interne de l'Institut Pasteur
The Berlin, London and Düsseldorf patients, «natural controllers» and «post-treatment controllers» all have one thing in common: they are all capable, in one way or another, of dealing with HIV without antiretroviral therapy. They all represent unique models to help scientists understand how the immune system is able to combat the virus, curb its progression or prevent viral reservoirs from being reactivated once treatment has been discontinued. They are an irreplaceable source of inspiration for improving future treatments, and they are now also serving as a springboard for promising new clinical trials, after four decades of observation and research at the Institut Pasteur.
This article is the fourth of a series dedicated to the hopes of HIV/AIDS research, on the occasion of the 40th anniversary of the identification of the virus.