Embryonic development – the role of Nodal in establishing cardiac asymmetry

Cardiac asymmetry established during embryonic development is critical to heart function. 1% of all newborns are affected by a heart defect, which in France accounts for approximately 8,000 babies per year. It is therefore essential to understand the mechanisms of heart formation in order to determine the causes of these defects. Sigolène Meilhac’s Heart Morphogenesis team at the Institut Pasteur and Imagine Institute are involved in work in this area. They have investigated the role of Nodal in cardiac asymmetry.

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