HIV: one stage in replication may occur in macrophage nuclei

Understanding the replication mechanisms of HIV in the body is vital for the development of more targeted treatments. Research into macrophages is particularly crucial, since these immune cells are the first line of cellular defense against infectious agents, and HIV accumulates silently in them, making them a reservoir for the virus – even in people receiving treatment. Scientists from the Institut Pasteur and the CNRS have shown that one of the stages in HIV replication may actually occur in the nucleus of macrophages. This finding challenges existing scientific knowledge and paves the way for new therapeutic targets.

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