The first "3D" metagenomics experiment on a complex natural microbiome

For the first time, a three-dimensional metagenomics experiment has been carried out on a mouse intestinal microbiota sample. This method quantifies and exploits 3D physical contacts between DNA molecules present in a mix of species, to infer their proximity. It is then possible to analyze interactions between bacterial and phage genomes. The study carried out on this complex natural environment highlights the effectiveness of new approaches in genomics.

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